Kurman et al. have published a review in the American Journal of Obstetrics and Gynecology arguing that aggressive ovarian cancer is often never confined to the ovary, and thus early detection methods that focus on finding low-stage localized tumors will miss these more common, more deadly cancers. They recommend refocusing research efforts from detecting early stage ovarian cancers to detecting aggressive but small volume cancers. Read the paper and tell us if you are convinced.